Keywords: calcium; MCU; MICU1; mitochondria; NCLX Introduction All membrane enclosed organelles (with the notable excep-tion of nucleus and peroxisomes that …
During the past two decades calcium (Ca2+) accumulation in energized mitochondria has emerged as a biological process of utmost physiological relevance.
Mitochondrial Ca (2+) uptake and release play a fundamental role in the control of different physiological processes, such as cytoplasmic Ca (2+) signalling, ATP …
Mitochondrial calcium (Ca 2+) homeostasis regulates aerobic metabolism, cell survival, cellular Ca 2+ signaling and mitochondrial reactive oxygen species (mROS) …
Mitochondria play vital role in regulating the cellular energetics and metabolism. Further, it is a signaling hub for cell survival and apoptotic pathways. One of the key determinants …
Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they have many physiological functions, prominently including muscle contraction, …
This chapter is primarily focused on the role of mitochondria in cellular Ca 2+ handling. Indeed, many subcellular compartments, including mitochondria, are key …
Calcium ions (Ca 2+) are ubiquitous second messengers that translate information delivered by extracellular and intracellular signals into an intracellular effect.
Here, we report cryo-EM structures of human mitochondrial calcium uniporter holocomplex in inhibited and Ca 2+-activated states. These structures define the architecture of this …
One of the key determinants that calibrate both cellular energetics and survival functions is mitochondrial calcium (Ca 2+) dynamics. Mitochondrial Ca 2+ …